ABOUT NOURELLA® WITH RETILEX-A® AND VERCILEX®

What is Nourella®?

Nourella® is a clinically proven, dual action anti-ageing therapy comprised of a topical cream and per oral tablets that, when used together, have a broad range of overlapping qualities that stimulate, rebuild, and rejuvenate the skin.

  • RetileX-A®: a proprietary, novel, next-generation, nano-encapsulated retinoid that utilises proprietary technology to enhance the efficacy of topical retinoids in rejuvenating the skin.
    RetileX-A® enhances the bioavailability of retinoids exactly where they are needed in the skin layers and imparts an extended-release profile. It is a “next-generation” retinoid, which means it drastically reduces risks like skin redness and burning that are normally associated with other commercially available retinoid treatments.
  • Vercilex®: a scientifically formulated natural bioactive complex rich in the specific proteoglycans involved in reviving the normal turnover of skin components, such as collagens and proteoglycans. The unique skin proteoglycans found in Nourella® tablets are essential for rejuvenating radiant, healthy, and younger looking skin.
What is Vercilex®?

Vercilex® is a fractionated fish extract with specific proteins and proteoglycans, produced in tablet formulation to treat skin ageing disorder and rejuvenate the skin. Vercilex® is made with the highest quality raw materials using an exclusive, protected enzymatic extraction technology and is accepted by health authorities on all continents of the globe including the FDA, Anvisa, Cofepris, and EFSA (European Food Safety Authority).

What is RetileX-A®?

RetileX-A® is nano-complex-encapsulated retinyl palmitate produced in cream form and used to treat skin ageing disorder and rejuvenate the skin. RetileX-A® utilises a sophisticated proprietary technology to nano-encapsulate and stabilise each hydrophobic molecule of retinyl in Nourella® cream. It increases the solubility and protects the active compounds in Nourella® cream from degradation and oxidation without altering the original molecular structure, and it provides a “buffering effect” that extends the absorption rate and duration of pharmacological activity of treatment while minimising potential retinoid side effects.

 

What makes Nourella® unique?

In contrast to most conventional skin rejuvenation and anti-ageing products on the market, Nourella® employs both a systemic (internal) and topical (external) approach to skin care.

The Nourella® approach is based on more than 30 years of research and development into Proteoglycan Replacement Therapy (PRT) and next-generation nano-encapsulated retinoids. Using innovative and proprietary technologies developed over decades, the efficacy of Nourella® has been meticulously assessed for efficacy and safety in multiple long-term published clinical papers involving thousands of individuals.

Nourella® is a safe, drug-free, and side effect free treatment option for addressing skin ageing.

How long does Nourella® take to work?

Most users experience results within two – four months.

Typically, after about six to eight weeks of use, the medium to long-term effects of Nourella® become visible as it begins to stimulate long-term natural skin rebuilding processes. By rebuilding fibroblast, collagen, and elastin, Nourella® reduces the appearance of fine lines and wrinkles, firming up and improving the uniform density of the skin – thereby regenerating a youthful feel and complexion.

In a published, randomised, double-blind clinical trial, three months of treatment with Nourella® cream with RetileX-A® led to a 31% increase in skin thickness when compared to conventional retinoid cream. During the same period, RetileX-A® induced an 18% improvement in skin elasticity. A subsequent trial indicated that 25% of the therapeutic effects of RetileX-A® on skin thickness and 23.4% on skin elasticity were still present one year after treatment cessation, indicating that Nourella® cream has lasting long-term benefits that extend well beyond its actual application period – unlike any creams currently available.

Read more here

The efficacy of Proteoglycan Replacement Therapy (PRT) with Nourella® tablets with Vercilex® is supported by several published clinical papers as well. After six months of treatment, Nourella® tablets produced significant improvements in objective measures of skin thickness (+34%) and elasticity (+32%) in individuals with chronologically aged skin. At the trial endpoint, the skin quality of the participants under Nourella® treatment was significantly higher when compared to their baseline values and to placebo users. Patient self-evaluation also showed that 90% of the individuals treated with Vercilex® reported an improvement in their skin quality, which was significantly greater than with placebo.

Read more here
How Do Nourella® tablets with Vercilex® work?

Vercilex® is rich in bioactive and bioavailable skin proteoglycans designed to revive the normal turnover of skin components such as collagens and proteoglycans. The unique complex in the Nourella® tablet formulation delays the process of skin ageing and revives healthy and youthful-looking skin through a process called Proteoglycan Replacement Therapy (PRT).

Skin PRT with Nourella® with Vercilex® is a novel therapeutic method that utilises repeated oral dosing of skin-specific proteoglycans, which are produced with marine-derived extracts (read more below). Oral administration of bioactive proteoglycans restores the diminished concentration and function of matrix proteoglycans in human skin that occurs during the ageing process, increasing both skin thickness and elasticity. PRT with Vercilex® is an ideal adjunctive therapy that improves the efficacy of topical treatment with Nourella® cream and counteracts skin ageing by:

  • Enhancing the concentration and synthesis of proteoglycans in the skin matrix
  • Improving collagen fibrillogenesis and stability
  • Promoting the activity of dermal keratinocytes and fibroblasts
  • Counteracting the uncontrolled oxidative and inflammatory processes in ageing skin
  • Preventing UV-induced skin damage, hypertrophy, and elastosis
How does Nourella® cream with RetileX-A® work?

Topical retinoids and retinoid esters are potentially effective anti-ageing compounds. However, their ability to penetrate the skin is crucial for their bioactivity. Very few ingredients in most conventional skin care creams can penetrate far enough into the skin to improve the key presentations of skin ageing such as deep wrinkles.

The smart technology used in RetileX-A® effectively encapsulates and protects each hydrophobic molecule of retinyl by forming a protective shell around it – a proprietary technology called nano-encapsulation – without altering the retinoids original structure and then releasing it later as it penetrates deeper into the skin.

This is important for two reasons:

First, nano-encapsulation helps eliminate a ‘retinoid reaction’, a common side effect of conventional topical retinoid usage, which manifests as redness from burning, dryness, tightness and peeling.

In conventional retinoid formulations, retinoid concentrations are proportionally correlated to the rate of side effects – meaning the more effective the product is, the more it will irritate and “burn” the skin. Nano-encapsulation is a smart method for providing efficacy and safety by minimising membrane contact time and irritation. At the same time, it enhances transdermal retinoid delivery.

Secondly, conventional retinoids are chemically and thermally unstable. They are notoriously sensitive to photo-isomerization and photo-destruction. Because about 80% of the retinoic acid in conventional products remains on the skin surface after application, a considerable amount of the applied dose will degrade before it has any chance of being absorbed into the skin. The nano-encapsulation found in RetileX-A® protects the sensitive retinoid molecules from degradation, increasing their longevity and efficacy.

RetileX-A® produces efficient full-thickness improvement in the structure and appearance of aged skin by:

  • Normalising the thickness and texture of the epidermis
  • Preventing the degradation of collagen and elastin
  • Stimulating the synthesis of collagen and elastin
  • Promoting angiogenesis and dermal blood perfusion
  • Providing antioxidant and anti-inflammatory activities
  • Depigmenting and inhibiting melanin synthesis
Is Nourella® the only product worldwide containing RetileX-A® and Vercilex®?

Yes.

Nourella® is the only product worldwide containing RetileX-A® and Vercilex®, both of which are intellectually protected and proprietary. Consumers should, therefore, be aware of imitation products that claim to deliver similar results as ‘next-generation’ retinoids or as ‘marine proteins’ or ‘marine extracts’ – these are not the original, clinically proven components found in Nourella®.

Clinical studies have shown that both RetileX-A® and Vercilex® produce significant anti-ageing results. Because some of these properties of the two ingredients overlap, combining these two active therapies gives synergistic effects and added efficacy.

Is Nourella® available without a prescription?

Yes.

While Nourella® is often dispersed on the advice of dermatologists, gynaecologists, and general practitioners, it is a drug-free product produced using natural ingredients.

Both Nourella® cream and tablets can be purchased without a prescription at clinics, pharmacies, and leading retail pharmacies.

Do you have to take both Nourella® cream and Nourella® tablets for it to work?

Nourella® is a Dual Action Therapy for Skin Rejuvenation that is developed to work both topically (on the skin) and systemically (from inside the body).

RetileX-A® cream and Vercilex® tablets possess a broad range of overlapping skin rejuvenating properties. A large, controlled, clinical trial verified the efficacy of this approach and evidenced that Nourella® Dual Action Therapy for Skin Rejuvenation produces significant anti-ageing benefits in individuals with a skin ageing disorder when Nourella® cream and tablets are used together. The effect size of dual action therapy in this trial was of a higher magnitude when compared with Nourella® monotherapy.

Read more here

The table below shows the benefits of dual action therapy for skin rejuvenation. To optimise therapeutic outcome, Nourella® cream and Nourella® tablets should be used together.

 

 

 

Where can I buy Nourella®?

Nourella® can be purchased without a prescription at clinics and leading retail pharmacies.

In some pharmacies, Nourella® cream with RetileX-A® and Nourella® tablets with Vercilex® may be shelved in separate locations. Be sure to ask your pharmacist for help in finding both products to ensure the full therapeutic outcome.

About proteoglycans and retinoids

What is RetileX-A®?

RetileX-A® sets Nourella® cream apart from all other topical, retinoid-based skin rejuvenation products on the market.

RetileX-A® (nano-complex-encapsulated retinyl palmitate) utilises a sophisticated proprietary technology to nano-encapsulate and stabilise each hydrophobic molecule of retinyl in Nourella® cream. RetileX-A® increases the solubility and protects the active compounds in Nourella® cream from degradation and oxidation without altering the original molecular structure, and it provides a “buffering effect” that extends the absorption rate and duration of pharmacological activity of treatment while minimising potential retinoid side effects. When used in combination with Nourella® tablets with Vercilex®, users can achieve synergistic effects and added clinical efficacy in treating their “Skin Ageing Disorder”.

As a next-generation retinoid, RetileX-A®:

  • Improves the overall absorbed dosage of retinyl by molecular stabilisation and reducing degradation
  • Optimises transdermal delivery and diffusion of the active compound (300x increase compared to conventional retinoids)
  • Extends the drug release and time available by its unique buffering effect
  • Prevents drug–drug and drug–excipient interactions by providing physical and chemical protection
  • Minimises adverse effects by restricting the contact time between the free retinoid and the skin surface
  • Enhances the stability and shelf life of Nourella® cream
What is Vercilex®?

Vercilex® is the key ingredient in Nourella® per oral tablet formulation.

Vercilex® is a fractionated fish extract with specific proteins and proteoglycans, produced in tablet form to treat skin ageing disorder and rejuvenate the skin. When used in combination with Nourella® cream with RetileX-A®, users can achieve synergistic effects and added clinical efficacy in treating their skin ageing disorder.

Pharma Medico has dedicated more than 30 years of research activity into developing Vercilex®, with a focus on:

  • Isolating the key proteoglycans involved in enhancing skin fibroblast/keratinocyte activity
  • Investigating the clinical effects of Proteoglycan Replacement Therapy with Vercilex® on both intrinsic and accelerated skin ageing in humans
  • Identifying the dose and time needed for Vercilex®to have an optimal therapeutic effect
  • Verifying the synergistic effect between Vercilex®and topical RetileX-A®  to develop a comprehensive anti-ageing approach

Vercilex® is made with the highest quality raw materials using an exclusive, protected enzymatic extraction technology and is accepted by health authorities on all continents, including: The FDA, Anvisa, Cofepris, and EFSA (European Food Safety Authority).

What are retinoids?

Retinoids are a class of chemical compounds that comprise different forms of vitamin A or are chemically related to vitamin A. Retinoids of different forms are used in cosmetics and medicine, primarily due to the way they regulate epithelial cell growth.

Retinoids have many important and diverse functions throughout the body, including regulation of cell proliferation and differentiation, and they have been proven to be particularly effective in treating certain skin disorders.

They are classed into three generations, with classification related to: how easily they convert to retinoic acid (their active form), their safety, and their side effects. Essentially, the stronger retinoids are in the crude form, the more effective they will be, but this also means the more side effects they will display in therapy. These side effects include things like reddening of the skin, increased sensitivity, itchiness, and dryness.

All retinoids in generations one to three are characterised by being extremely sensitive to light, and, in general, the retinol used in most conventional antiaging creams is quickly broken down by light once applied to the skin. This means that with many conventional skin care products a large proportion of the active components are never delivered to the lower skin layers – where the effect is actually needed.

RetileX-A® is a next-generation retinoid, developed through 30 years of research and development and unique to Nourella®. RetileX-A® uses a novel technology which envelops a retinoid molecule in a carrier system that allows the molecule to penetrate deeply to the layers of the skin. This ‘envelope’ protects each molecule from light and oxidation, carrying them directly to the keratinocytes in the skin where molecules are then released and can exert their efficacy. Current conventional retinoids in generations one – three are unable to penetrate even the top layers of skin before they are broken down.

Next-generation retinoids, like RetileX-A®, amplify the anti-ageing efficacy of topical retinoids by maximising their target tissue concentration. Once in the skin, RetileX-A® becomes hydrolysed and metabolised to provide the powerful anti-ageing effect like that of retinoic acid, but without the associated side effects mentioned above.

What are proteoglycans?

Proteoglycans (PGs), a family of glycosaminoglycan (GAG) conjugated proteins, are important constituents of human skin connective tissue (dermis) and are essential for maintaining the mechanical strength of the skin.

Skin proteoglycans are highly bioactive and contribute to tissue hydration, resistance, and resilience by forming super-molecular structures with matrix proteins. More than 40 biological proteoglycans are expressed in skin tissues, the most abundant being versican, decorin, biglycan and syndecan-1.

In aged skin, the total amount of sulphated glycosaminoglycans reduces in the dermis (in both sexes) and epidermis (only in women) during the intrinsic ageing process.

The molecular characteristics of proteoglycans, i.e., the number and size of glycan side chains and cleavage products, are affected as a function of age, thus their biological function is disturbed. This phenomenon is a result of the gradual loss of the function of glycosaminoglycan synthesising enzymes.

Nourella® with Vercilex® is formulated to help restore the diminished concentration and function of bioactive proteoglycans that occurs during the process of ageing in human skin.

How does RetileX-A® improve skin quality?

Topical retinoids and retinoid esters are potentially effective anti-ageing compounds. However, their ability to penetrate the skin is crucial for their bioactivity. Despite this, very few ingredients in most skin care products have the capacity to penetrate far enough into the skin to improve the key presentations of skin ageing such as deep wrinkles.

RetileX-A® technology effectively encapsulates and protects each hydrophobic molecule of retinyl palmitate by forming a protective shell around it – without altering its original structure.

This is important for two reasons:

First, nano-encapsulation helps eliminate a ‘retinoid reaction’, a common side effect of conventional topical retinoid usage, which manifests as redness from burning, dryness, tightness and peeling.

In conventional retinoid formulations, retinoid concentrations are proportionally correlated to the rate of side effects – meaning the more effective the product is, the more it will irritate and “burn” the skin. Nano-encapsulation is a smart method for providing efficacy and safety by minimising membrane contact time and irritation. At the same time, it enhances transdermal retinoid delivery.

Secondly, conventional retinoids are chemically and thermally unstable. They are notoriously sensitive to photo-isomerization and photo-destruction. Because about 80% of the retinoic acid in conventional products remains on the skin surface after application, a considerable amount of the applied dose will degrade before it has any chance of being absorbed into the skin. The nano-encapsulation found in RetileX-A® protects the sensitive retinoid molecules from degradation, increasing their longevity and efficacy.

RetileX-A® produces efficient full-thickness improvement in the structure and appearance of aged skin by:

  • Normalising the thickness and texture of the epidermis
  • Preventing the degradation of collagen and elastin
  • Stimulating the synthesis of collagen and elastin
  • Promoting angiogenesis and dermal blood perfusion
  • Providing antioxidant and anti-inflammatory activities
  • Depigmenting and inhibiting melanin synthesis
What is Vercilex® Skin Proteoglycan Replacement Therapy?

During the process of skin ageing, intrinsic factors (genetic, physiological, and pathological characteristics) and extrinsic factors (environmental, cultural, or lifestyle) lead to structural and functional changes in the skin’s extracellular matrix components (collagens, elastin, and proteoglycans). These components provide tensile strength, elasticity, and hydration.

Skin Proteoglycan Replacement Therapy (PRT) is a unique per oral treatment implementing a targeted combination of specific, natural, marine proteoglycans – branded as Vercilex® – which restore the diminished concentration and function of bioactive proteoglycans in human skin that occurs during the ageing process.

Vercilex® was developed by Pharma Medico in Scandinavia after more than 30 years of research as a therapeutic answer to this unmet clinical need. This sophisticated, bioactive complex is strenuously extracted through a proprietary enzymatic process to maximise the concentration of specific proteoglycans that are affected by skin ageing.

ABOUT SAFETY AND SIDE EFFECTS

Is Nourella® approved for use in my country?

Health authorities on all continents have approved Nourella®, RetileX-A®, and Vercilex® – including the FDA, Anvisa, Cofepris, and EFSA (European Food Safety Authority).

Is Nourella® safe to use?

Yes.

Nourella® with RetileX-A® and Vercilex® are based entirely on drug-free ingredients, which are evaluated as safe by food and drug authorities globally.

The safety and side-effect-free tolerability of Nourella® has been demonstrated in multiple clinical trials featured in leading international clinical and medical journals. Furthermore, health authorities on all continents have approved Nourella®, RetileX-A®, and Vercilex® – including the FDA, Anvisa, Cofepris and EFSA (European Food Safety Authority).

Nourella® tablets with Vercilex® should not be taken by people who are allergic to fish.

Read more here
Are there any side effects from taking Nourella®?

Side effects are rare, but should a skin reaction occur during the application of Nourella® cream, decrease the frequency of application. If the problem persists, cease treatment temporarily.

During the first months of treatment with Nourella® cream, individuals are advised to avoid excessive sun exposure and use sunscreen of at least SPF 15 during exposure.

There are no known side effects from Vercilex®, but users who are allergic to fish should avoid taking Nourella® tablets.

Will Nourella® cream cause redness or burning on my skin?

No.

The unique nano-encapsulation technology in RetileX-A® that is the key ingredient in Nourella® cream helps eliminate ‘retinoid reaction’ or ‘retinoid burn’, which is characterised by redness, swelling, or drying of the skin and can be a common side effect of conventional topical retinoid use.

During the first months of treatment with Nourella® cream, individuals are advised to avoid excessive sun exposure and use sunscreen of at least SPF 15 during exposure.

If any skin reaction occurs during the application of Nourella® cream and does not subside with decreasing the frequency of use, cease treatment temporarily.

Does Nourella® interfere with any medication?

There are no known or recorded interactions between Nourella® tablets and other supplements and medications, but caution should be exercised when using Nourella® cream concomitantly with medicated or abrasive soaps, creams, and cleansers.

Is Nourella® suitable for everyone?

Nourella® is suitable for everyone over the age of seven except those with allergies to fish. Nourella® tablets with Vercilex® are produced with fish-derived extracts. Nourella® does not contain shellfish.

Nourella® is entirely based on drug-free ingredients, which are evaluated as safe by food and drug authorities globally. Nourella® is gluten-free and, therefore, suitable for coeliacs.

Furthermore, health authorities on all continents accept Nourella®, RetileX-A®, and Vercilex® including the FDA, Anvisa, Cofepris, and EFSA (European Food Safety Authority).

Is Nourella® safe and suitable for sensitive skin?

Yes, Nourella® is safe and suitable for all skin types.

During the first months of treatment with Nourella® cream, individuals are advised to avoid excessive sun exposure and use sunscreen of at least SPF 15 during exposure.

If any skin reactions connected with the application of Nourella® cream against all expectations should occur and do not subside with decreasing the frequency of use, treatment should be temporarily discontinued.

ABOUT DOSAGE AND ADMINISTRATION

How often should I use Nourella®?

The recommended dosage for Nourella® cream with RetileX-A® is twice daily, in the morning and at bedtime, to the cleansed skin of target areas including the face and decolletage. Gently distribute the cream onto the skin from inside and outwards, then lightly tap and massage to accelerate absorption. Allow a few minutes between applying Nourella® cream and using makeup products. Most users see results within 2-4 months, with optimal results at 4-6 months.

For Nourella® tablets with Vercilex®, the recommended dosage is 2 tablets daily, 1 in the morning and 1 in the evening, preferably after food.

Does Nourella® interfere with any medication?

There are no known interactions between Nourella® tablets and other supplements and medications.

Can Nourella® be taken for longer periods of time?

Nourella® is safe to take for indefinite periods and is ideal for long-term skin maintenance and skin rejuvenation even after the desired results have been achieved.

Most users see results after 2-4 months.

From 6-8 weeks of use, the medium to long-term effects of Nourella® become visible as it stimulates the long-term natural skin rebuilding process. By rebuilding fibroblast, collagen, and elastin, Nourella® reduces the appearance of fine lines, wrinkles, and firms up the skin while improving the uniform density of the skin.

What happens if I stop taking Nourella®?

Nourella® Dual Action Therapy for Skin Rejuvenation provides long-lasting therapeutic benefits – both on the surface and below the surface of the skin. Increased skin elasticity, increased moisture retention, collagen rebuilding, increased skin density, and diminished appearance of fine lines and wrinkles are among the results users can expect.

In one published clinical study, Dual Action Therapy reversed skin characteristics among participants with an average age of 48 by ‘over 20 years’ to the point that their skin presented the features of persons in their 30’s. This clinical efficacy, verified objectively, represents a unique ‘Age Reversing Effect’ of the Nourella® Dual Action Therapy for Skin Rejuvenation.

Other studies have shown that 25% of efficacy results remain in the skin even after 12 months’ cessation of use.

Read more here
Can I use Nourella® for longer than 6 months?

Yes.

Nourella® is ideal for long-term maintenance of healthy skin and can be safely used on a long-term basis to stimulate, rebuild, and rejuvenate the skin.

Will taking more than the recommended dosage increase the speed or quality of my skin’s appearance?

No.

The recommended administration and dosage of Nourella® has been part of a 30-year research and development effort. During that time, clinical studies have helped define the optimal dosing recommendations and it has been demonstrated that intake of more than the recommended daily dosage, as described on the specific product packaging, provides no significant added benefits.

Nourella® is not a miracle product and users should not expect immediate results – it takes time for the active ingredients in the recommended dosages to take effect.  Most users begin to see results after 2-4 months of use.

ABOUT SKIN AGEING

What causes skin ageing?

After the age of 20, normal skin ageing occurs at a steady rate as a function of age. As we grow older, our skin inevitably becomes less elastic and thinner due to a decrease in collagen and elastin in the skin.

It is now well recognised that ageing is a complex, multi-factorial phenomenon that is a consequence of both genetic programming (intrinsic factors) and cumulative environmental damage (extrinsic factors).

Internal factors that underlie ‘intrinsic skin ageing’ include:

  • Cellular ageing
  • Shortening of telomeres
  • Genetic mutations
  • Oxidative stress
  • Hormonal changes

While some of the external factors that cause ‘extrinsic skin ageing’ are:

  • UV exposure
  • Stress
  • Pollution

Together, both classes of aetiological factors contribute to a progressive loss of structural integrity and physiological tasks of the skin that give rise to a range of clinical symptoms. Because of this, skin ageing is a ‘disorder’ in the same sense of other medical disorders and one that warrants treatment.

Is skin ageing a disorder?

Yes.

Whether or not a health condition is recognised as a disease/disorder depends on its historical context and several technological and social factors. Several currently recognised disorders, such as osteoporosis and senile Alzheimer’s disease, were in the past known as normal results of ageing.

In the same manner, skin ageing is still considered by some to be a ‘normal consequence’ of the ageing process, whereas it fully meets the accepted criteria for a ‘disorder’.

How can I prevent (or at least slow) the appearance of wrinkles?

Skin wrinkling, skin sagging, and skin thinning are all visible clinical symptoms of skin ageing.

Skin ageing is now recognised as a complex and multi-factorial ‘disorder’ with a multiplicity of internal and external aetiological factors. Decades of research show that by addressing a sufficient number of these causative factors, the skin ageing ‘disorder’ can be delayed and treated.

A variety of invasive and non-invasive methods have been introduced to address different aspects of skin ageing; however, topical retinoids remain the gold standard treatment. Still, conventional formulations of retinoids bear a fundamental shortcoming: The more potent they are, the more intolerable they become and the more side effects they produce. This direct association between efficacy and the rate of side effects largely limits the application of conventional retinoids in treating the aged skin.

Nourella® Dual Action Therapy for Skin Rejuvenation, comprised of topical nano-encapsulated RetileX-A®, addresses this treatment challenge, providing the efficacy of high-potency retinoids and allowing them to penetrate deep into wrinkles in the skin without exhibiting the limiting side effects of normal conventional retinoids.

When combined with per oral Vercilex®, which provides Skin Proteoglycan Replacement Therapy to reverse the decay of microfibrils and revive skin texture and elasticity, users can achieve a unique dual action skin therapy treatment with proven age reversing effects.

What role do skin proteoglycans play in skin ageing?

Skin proteoglycans contribute to tissue hydration, resistance, and resilience of the skin by forming super-molecular structures with matrix proteins. They also control cell behaviours and interactions.

In intrinsically aged skin, a marked decay occurs in the concentration of the proteoglycans perlecan, biglycan, decorin, and syndecan-1 under the outer surface of the skin. This leads to a reduction in the synthesis of extracellular matrix proteins which are expressed by the typical clinical symptoms of skin ageing, including: thin and transparent skin, skin fragility, age spots, wrinkles, and sagging

Furthermore, the molecular characteristics of skin proteoglycans are also affected as a function of age. Poor functionality of proteoglycans is involved in age-related changes in collagen turnover and assembly.

What does skin ageing mean for one’s overall quality of life?

Research confirms that the nuisances of skin ageing have profound effects on one’s overall quality of life and skin ageing, age spots (solar lentigines), and wrinkles and sagging can have psychosocial consequences which should be given special attention.

The unappealing appearance of a senescent skin may negatively affect body-image and self-esteem of the person and result in anxiety and depression. Skin ageing can also repel physical contact by others, leading to social withdrawal and the obstruction of inter-personal relationships.

TREATING SKIN AGEING

Can skin ageing really be treated?

Yes, it can.

The process of skin ageing does not progress at a steady non-variable rate. On the contrary, mounting evidence suggests that the rate of skin ageing depends on a combination of intrinsic factors (genetic, physiological, and pathological characteristics) and extrinsic factors (environmental, cultural, or lifestyle).

It is thus feasible to retard or even reverse the process of skin ageing by altering relevant factors, e.g., by avoiding the modifiable risk factors (unprotected sun exposure or smoking) and to treat them through pharmaceutical intervention.

What options are available for treating skin ageing?

Conventional anti-ageing strategies can be classified into per oral supplements, topical products, and invasive techniques – such as injections, skin peeling, and laser tightening.

Per oral skin rejuvenation therapies have recently obtained a footing in the clinical management of skin ageing. Products containing different combinations of antioxidants and herbal extracts have been tried with very mixed results. However, the clinical treatment of choice or the ‘Gold Standard’ that benefits both intrinsically aged and photoaged skin is the topical application of certain prescriptive retinoids. Regular use of these agents has proven efficacy in preventing and treating the main symptoms of skin ageing.

Still, conventional formulations of retinoids bear a fundamental shortcoming: The more potent they are, the more intolerable they become and the more side effects they produce.

Nourella® Dual Action Therapy for Skin Rejuvenation, comprised of topical nano-encapsulated RetileX-A®, addresses this treatment challenge, providing the efficacy of high-potency retinoids without their limiting side effects.

When combined with per oral Vercilex®, which provides Skin Proteoglycan Replacement Therapy to reverse the decay of microfibrils and revive skin texture and elasticity, users can achieve a unique dual action skin therapy treatment with proven age reversing effects.

What makes Nourella® unique?

In contrast to most conventional skin rejuvenation and anti-ageing products on the market, Nourella® employs both a systemic (internal) and topical (external) approach to skin care.

Consisting of both a topical cream that is applied to the skin and tablets that are taken orally, the Nourella® Dual Action Therapy for Skin Rejuvenation is a unique therapeutic approach to skin care based on more than 30 years of research and development into Proteoglycan Replacement Therapy and next-generation nano-encapsulated retinoids. Using innovative and proprietary technologies developed over time, the efficacy of Nourella® has been meticulously assessed for safety and efficacy in multiple long-term clinical studies.

How long does it take to see results?

Most users begin to see improvement after two to four months.

Typically, after about six-eight weeks of use, the medium to long-term effects of Nourella® become visible as it begins to stimulate the long-term natural skin rebuilding process. By rebuilding fibroblast, collagen, and elastin, Nourella® reduces the appearance of fine lines and wrinkles, firming up and improving the uniform density of the skin.

In a randomised, double-blind clinical trial, three months of treatment with Nourella® RetileX-A® led to a 31% increase in skin thickness when compared to conventional retinoid cream. During the same period, RetileX-A® induced an 18% improvement in skin elasticity. A subsequent trial indicated that 25% of the therapeutic effects of RetileX-A® on skin thickness and 23.4% on skin elasticity were still present one year after treatment cessation, indicating that Nourella® cream has lasting long-term benefits that extend well beyond its actual application period.

Read more here

The efficacy of Proteoglycan Replacement Therapy (PRT) with Nourella® Vercilex® tablets is supported by several published clinical papers as well. After 6 months of treatment, Nourella® tablets produced significant improvements in objective measures of skin thickness (+34%) and elasticity (+32%) in individuals with chronologically aged skin. At the trial endpoint, the skin quality of the participants under Nourella® treatment was significantly higher when compared to their baseline values and to placebo users. Patient self-evaluation also showed that 90% of the individuals treated with Vercilex® noticed an improvement in their skin quality, which was significantly greater than with placebo.

Read more here